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FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF PROCHLORPERAZINE MALEATE - RESULT AND DISCUSSION

    results and discussion   The sample of promethazine theoclate was analyzed by various organoleptic, physicochemical and spectrophotometric methods. The sample of promethazine theoclate possessed similar color, odor, taste and texture as given in officials. The melting point of the sample was analyzed by capillary fusion method and found to be 2310. The FTIR spectrum of promethazine theoclate sample was concordant with reference spectra as given in Clarke Analysis of Drug. The FTIR spectra of reference and sample are shown in Fig respectively. The FTIR spectra verified the authenticity of the procured sample as the characteristic peaks of the promethazine theoclate was found at 749, 1160, 1220, 1259 cm-1 in concordance to the reference spectra. The qualitative solubility of promethazine theoclate was determined in various sol vents. The maximum solubility was found in chloroform and least in ether and acetone. The result for solubility of promethazine theoclate in various solv

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF PROCHLORPERAZINE MALEATE - MATERIALS

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    MATERIALS   LIST OF CHEMICALS   Category Material Manufacturer Drugs Prochloperazine Maleate Mehta Pharmaceuticals, Mumbai Promethazine Theoclate Mehta Pharmaceuticals, Mumbai Cisplatin IV Injection Pfizer (Perth) Pty Ltd., Australia Disintegrants Croscamellose Sodium Signet Chemicals, Mumbai Crospovidone Signet Chemicals, Mumbai Sodium Starch Glycolate Signet Chemicals, Mumbai Effervescent Agents Sodium Bi Carbonate (AR) Central Drug House (P) Ltd., Mumbai Citric Acid Central Drug House (P) Ltd., Mumbai Sublimating Agents Menthol Central Drug House (P) Ltd., Mumbai Camphor Central Drug House (P) Ltd., Mumbai Thymol Central Drug House (P) Ltd., Mumbai