FORMULATION AND EVALUATION OF EXTENDED RELEASE MICROCAPSULES OF LAMIVUDINE - REVIEW OF LITERATURE
REVIEW OF LITERATURE Literature review shows that no work has been published on the extended release micro capsule of Diltiazem HCL. Some of the published reports of similar work for various medicinal agents are: v Samal et al. developed oral sustained release matrix tablets of an antiretroviral drug, zidovudine. Matrix tablets were prepared by wet granulation method using various proportions of hydrophilic polymers like Sodium CMC, HPMC, Eudragit ‐ L155, & Xanthan gum along or in combination with hydrophobic polymer ethyl cellulose. The release kinetics was analyzed using zero order, first order, Higuchi and Hixson Crowell model. From this study it was concluded that presence of sodium CMC gives zero ‐ order release kinetics and the linearity ranges from 0.990 to 0.996. It has also good drug entrapment efficiency ranging from 96 to 106% of drug. Form...