CHEMICAL TEST FOR THE IDENTIFICATION OF UNORGANIZED DRUGS

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CHEMICAL TEST FOR THE IDENTIFICATION OF UNORGANIZED DRUGS
Chemical test for  Acacia =Indian gum
Organoleptic test:
Appearance: Crystalline                                                          agar, acacia
Colour: Pale yellow                                                                 acacia
Odour: Odourless                                                                   acacia
Taste: Bland and mucilaginous                                               acacia
Solubility: Soluble in water, insoluble in alcohol                    acacia
Chemical test:
Prepare a solution of acacia by adding 10ml of water to 0.5gm of acacia, stirring well.
Use this solution for following test.
SI.No.
Test
Observation
Inference

1.
Solubility
Soluble in water and insoluble in alcohol
Gum acacia present
2.
To 2ml solution add 50mg of borax, boil and cool
Stiff translucent mass is formed
Acacia present
3.
To the aqueous solution add few drops of dilute solution of lead sub acetate
White precipitate is formed
Gum acacia present
4.
Differenciating test from Guar Gum:
Gum acacia solution + 0.5ml hydrogen peroxide solution, shake vigrously.
Blue colour is produced
Presence of oxidase enzyme in acacia
5.
To 1ml of solution add 4ml water and few drops of conc.HCl, boil over water bath for few minutes cool and add NaOH to neutralize excess acid, add Fehling’s solution A and B(Mixed together before adding) in equal quantities and warm.
Formation of  brick red precipitate
Reducing sugars are present
6.
Differentiating test from Agar and Isapgol:
Gum acacia + Ruthenium red solution
No pink colour
Gum acacia
7.
Gum acacia solution + dil HCl boil for few minutes + few drops of Barium chloride solution
No white precipitate of barium sulphate.
Gum acacia present
8.
5ml aqueous solution of acacia add 0.5ml of hydrogen peroxide (10%) and 0.5ml of 1% solution of benzidine in (90%) alcohol, shake and allow to stand
Formation of blue colour
Presence of peroxidase enzyme in acacia
                        Test for Purity:
SI.No.
Test
Observation
Inference

1.
1ml of gum + 10ml of water on standing for few hours
No sedementation of particles
Pure acacia
2.
1ml of gum + 4ml of water + lead acetate solution
No precipitate
Pure acacia


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