ANTIANXIETY PROPERTY OF BASELLA ALBA LINN LEAVES EXTRACT IN EXPERIMENTAL ANIMALS - CONCLUSION

 

7. CONCLUSION

 

The results obtained from these experimental models clearly confirmed that the anxiolytic activity of aqueous and ethanolic extracts of Basella alba leaves. The acute toxicity study conducted for aqueous and ethanolic extracts indicates that they are safe up to 2000mg/kg body weight.

The acute treatment with both extract (aqueous and ethanolic) at 400 mg/kg had significant result but not on all recorded parameters whereas the both extracts at 800 mg/kg had significant positive result on all above recorded parameters so clearly demonstrate a dose dependant anxiolytic effect comparable to standard diazepam (2mg/kg) in all experimental models of anxiety. Ethanolic extract  shown more anxiolytic effective as compare to aqueous extract. 

           Earlier reports on the chemical constituents of the plants and their pharmacology suggests that the plant containing flavonoids, saponins and   tannins possess activity against many CNS disorders³⁵.

           Phytochemical tests of AEBAL and EEBAL revealed the presence of flavonoids. It may possible that the mechanism of anxiolytic action of AEBAL and EEBAL could be due to the binding of any of theseN phytochemicals to the GABAA-BZD complex. In support of this, it has been found that flavones bind with high affinity BZD site of the GABAA receptor³⁶. The flowers of Basella alba plant contains flavones which may responsible for its   anxiolytic activity.  So the anxiolytic activity of AEBAL and EEBAL might involve an action on GABAergic transmission or effects on serotonergic transmission or due to its mixed aminergic potentiating effect.

          However, the mechanism and the phytoconstituents responsible for anxiolytic activity of  Basella alba leaves extracts is unclear, hence it requires further studies to elucidate the possible mechanism involved in observe central effects and its use in human beings.