FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF PROCHLORPERAZINE MALEATE - OBJECTIVES
OBJECTIVES AND PLAN OF WORK
The objective of present research work was to optimize, formulate and evaluate different formulations of fast dissolving tablet(s) of anti-emetic drug prochlorperazine maleate and promethazine theoclate to achieve faster drug release to control in nausea and vomiting.
The present
work was an attempt:
1.
To develop Fast
dissolving tablet contains prochlorperazine maleate by using special excipient
like superdisintegrants alone or with combinations.
2.
To evaluate for the
pre-compression characteristics of powder mixture like bulk density, flow
property, angle of repose, compressibility index etc.
3.
To evaluate the
post-compression characteristics of the tablet like hardness, friability,
disintegration time, dispersion time, wetting time and water absorption ratio
etc.
4.
To carry out in
vitro dissolution studies of the tablet formulations.
5.
To carry out
stability studies according to ICH guidelines.
PLAN OF WORK
METHOD OF
COLLECTION OF DATA:
1.
The selected drug
was characterized and evaluated for its physicochemical properties like
solubility and compatibility with excipients.
2.
To identify the
suitable excipients alone or in combine for further processing.
3.
To carry out
pre-formulation studies like organoleptic properties, Bulk density, tapped
density, Angle of repose, Compressibility index of the powder mixture (drug and
excipients).
4.
To formulate
various formulations of the drug containing different ratio of the
superdisintegrant alone or in combination.
5.
To evaluate the
compressed tablet for hardness, friability, disintegration time, In-vitro
dispersion time, wetting time and In-vitro dissolution time, etc.
6.
The optimized
formulation will be subjected to stability studies according to ICH guidelines.
7.
The data so
obtained will be subjected for statistical analysis.
8.
The selected drug
shall be characterized and evaluated for its physicochemical properties like
solubility and compatibility with excipients.
9.
To identify the
suitable excipients alone or in combine for further processing.
10. To carry out pre-formulation studies like organoleptic properties,
Bulk density, tapped density, Angle of repose, Compressibility index of the
powder mixture (drug and excipients).
11. To formulate various formulations of the drug containing different
ratio of the superdisintegrant alone or in combination.
12. To evaluate the compressed tablet for hardness, friability,
disintegration time, In-vitro dispersion time, wetting time and In-vitro
dissolution time, etc.
13. The optimized formulation will be subjected to stability studies
according to ICH guidelines.
14. The data so obtained will be subjected for statistical analysis.
The
preliminary data required for the experimental study was obtained from
1.
CD-Rom search
available at National Center for Scientific Information (NCSI), Indian
institute of Sciences (IISc), Bangalore.
2.
Journals,
3.
Analytical
chemistry Books ,
4.
Library,
5.
Relevant Books,
6.
Internet Sources ,
7.
Scientific
abstracts.
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