ANALYSIS OF ABNORMAL CONSTITUENTS IN URINE
ANALYSIS OF
ABNORMAL CONSTITUENTS IN URINE
Metabolic disorders in most
common diseases are readily reflected in the composition of the urine of such
patients. So analysis of the urine for such abnormal constituents is of great
diagnostic value. Examples are the presence of protein, glucose, blood ketone
bodies, bile pigments, bile salts etc.
Many of the pathological constituents
are present in trace amounts in normal urine, but they escape detection due to
the low sensitivity of the methods employed. The concentration of these constituents
in urine are marked, increased in different pathological condition. Usua1ly the
analysis is carried out in properly preserved 24hours urine specimens. When
this is not possible the early morning specimen can be used. On standing urine
undergoes bacterial fermentation, it can be preserved under refrigeration or
using chemicals such as toluene or chloroform.
A. Physical characteristics in
pathological condition:
1) Volume:
An increase in urinary output
(polyuria) occurs in diabetes mellitus and diabetes insipidus and after administration
of drugs like digitalis and salicylates etc. A diminished urinary excretion (Oliguria)
occur in nephritis, fever and during diarrhea and vomiting. A total suppression
or urine formation (anuria) may occur during shock, acute nephritis,
incompatible blood transfusion, mercury poisoning and bilateral renal stone
formation.
2) Colour:
The urine becomes smoky brown
when blood is present. When bilirubin is present the colour will be yellow,
melanin makes the urine black. The urine is milky in appearance due to the
presence of bacterial or epithelial cells and lipids.
3) Reaction:
Acidic urine is voided in fever
and diabetes. Alkali therapy and urinary retention make urine alkaline.
4) Specific gravity:
Specific gravity is increased in
acute nephritis and fever and decreased in diabetes in-sipidus.
b) Chemical constituents:
The abnormal constituents which
are routinely looked for in urine are albumin, glucose, ketone bodies, bile
salts, bilirubin and blood.
Comments
Post a Comment