INHIBITION OF ALPHA-AMYLASE
INHIBITION OF ALPHA-AMYLASE
α-Amylase is a well-known therapeutic target for the treatment and
maintenance of postprandial blood glucose elevations.
The fasting glucose level of a non-diabetic human ranges between 70 to 100
mg/dL, and for a diabetic patient, the fasting blood glucose level ranges from
100 to 140 mg/dL. A postprandial condition is defined as a drastic increase in
the blood glucose level after the ingestion of food. In no diabetic humans the
range shifts between 100 to 140 mg/dL whereas in a diabetic patient it would
range between 140 to 190 mg/dL, which could be of higher risk for a
hyperglycemic person.
On the inhibition of the alpha-amylase the action of amylase on the starch
molecule is technically prevented thus slowing down the digestion of starch,
apparently controlling the postprandial condition.
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