SYNTHESIS OF FLAVANONES FROM CHALCONES
SYNTHESIS OF FLAVANONES FROM CHALCONES
PROCEDURE:
➢ To a solution of chalcone (1 eq) in methanol (10 mL) 5 equiv. of sodium
acetate (NaOAc) was added.
➢ The mixture was heated to reflux for 24 hrs and was monitored by TLC.
The solvent was evaporated, EtOAc (20 mL) was added, and the
mixture was washed with distilled water (3 × 20 mL).
➢ The solution was dried over anhydrous Na2SO4 and filtered.
➢ The solvent was evaporated under reduced pressure, and the residue
was purified by column chromatography (CC) using 60-120 mesh silica
as a stationary phase to give respective flavanone.
Here the 12 Flavanone that we have tried to synthesize with the respective
Chalcones but some of them we were not able to separate due to very less
polarity difference.
1. Syringaldehyde:
*This reaction did not proceed further. Hence there is no result for this reaction.
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