ORAL DRUGS TAKEN FOR THE ACTIVATION OF AMPK

Metformin: Metformin is an oral medication commonly used to treat type 2

diabetes. While its primary mode of action is through improving insulin

sensitivity and reducing glucose production in the liver, it is believed to

activate AMPK indirectly. Metformin has been shown to increase AMPK

activity in various tissues, leading to improved energy balance and metabolic

effects.

AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide): AICAR is a

nucleotide analog that can be taken up by cells and converted to ZMP, a

molecule that directly activates AMPK. AICAR is not approved as a drug but

is used in research to study AMPK signaling and its effects on cellular

metabolism.

A-769662: A-769662 is a synthetic compound that directly activates AMPK by

binding to its γ-subunit, similar to AMP. It has been shown to stimulate

glucose uptake in skeletal muscle and has potential therapeutic applications in

diabetes and metabolic disorders.

Resveratrol: Resveratrol is a naturally occurring polyphenol found in grapes,

berries, and some other plants. It has been suggested to activate AMPK

indirectly by increasing cellular AMP levels, although the exact mechanism is

still not fully understood15.

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